When the three witches — now old, remarried and widowed — decide to go back to Eastwick to spend a summer together, many things have changed. Darryl Van Horne is gone. Their husbands and lovers have gone. The lithe and supple bodies with which they wrecked marriages and wreaked havoc many years before have gone.

It's 1989, and Harry 'Rabbit' Angstrom is far from restful. Fifty-six and overweight, he has a struggling business on his hands and a heart that is starting to fail. His family, too, are giving him cause for concern. His son Nelson is a wreck of a man, a cocaine addict with shattered self-respect. Janice, his wife, has decided that she wants to be a working girl. And as for Pru, his daughter-in-law, she seems to be sending out signals to Rabbit that he knows he should ignore, but somehow can't. He has to make the most of life, after all. He doesn't have much time left.

Tristao Raposo, a nineteen-year old black child of the Rio slums, spies Isabel Leme, an eighteen-year-old upper-class white girl, across the hot sands of Copacabana Beach, and presents her with a ring. Their flight into marriage takes them from urban banality to the farthest reaches of Brazil's wild west....

It's 1969, and the times are changing. America is about to land a man on the moon, the Vietnamese war is in full swing, and racial tension is on the rise. Things just aren't as simple as they used to be — at least, not for Rabbit Angstrom. His wife has left him with his teenage son, his job is under threat and his mother is dying. Suddenly, into his confused life — and home — comes Jill, an eighteen-year-old runaway who becomes his lover. But when she invites her friend to stay, a young black radical named Skeeter, the pair's fragile harmony soon begins to fail...

It's 1979 and Rabbit is no longer running. He's walking, and beginning to get out of breath. That's OK, though — it gives him the chance to enjoy the wealth that comes with middle age. It's all in place: he's Chief Sales Representative and co-owner of Springer motors; his wife, at home or in the club, is keeping trim; he wears good suits, and the cash is pouring in. So why is it that he finds it so hard to accept the way things have turned out? And why, when he looks at his family, is he haunted by regrets about all those lives he'll never live?