Harriet Vanger, a scion of one of Sweden's wealthiest families, disappeared over forty years ago. All these years later, her aged uncle continues to seek the truth. He hires Mikael Blomkvist, a crusading journalist recently trapped by a libel conviction, to investigate. He is aided by the pierced and tattooed punk prodigy Lisbeth Salander. Together they tap into a vein of unfathomable iniquity and astonishing corruption.

Crusading publisher Mikael Blomkvist has decided to run an explosive expose of a wide-ranging sex trafficking operation. Just before the piece is published, the two reporters responsible are murdered. The fingerprints on the murder weapon belong to his friend, the troubled hacker genius Lisbeth Salander. Blomkvist, convinced of Salander's innocence, plunges into an investigation. Meanwhile, Lisbeth herself is drawn into a murderous game of cat and mouse, and is forced her to face her dark past.